Crhr2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comCrhr2 Polyclonal Antibody for Mouse(Mus musculus)

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Crhr2 (Gene name),

Corticotropin-releasing factor receptor 2 (Protein name ), CRFR2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Crhr2(Crf2r);

Protein name:

Corticotropin-releasing factor receptor 2(CRF-R-2;CRF-R2;CRFR-2);

Alternative:

Corticotropin-releasing hormone receptor 2(CRH-R-2;CRH-R2);CRF-RB;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CRF, UCN, UCN2 and UCN3.

Function:

This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

431

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

431:

HALRVPVARA | MSIPTSPTRI | SFHSIKQTAA | V

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q60748

UniGene:

Mm.236081

String:

Q60748

Pfam:

PF00002

Uniprot:

Q60748

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ELISA Kit for Mouse CRF-R-2

Cat.:

E0241h

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Packing:

96T

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ELISA Kit for Mouse CRF-R-2

Cat.:

E0241r

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96T

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ELISA Kit for Mouse CRF-R-2

Cat.:

E0241m

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96T

CLIA Kit for Mouse CRF-R-2

Cat.:

U0241h

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96T

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CLIA Kit for Mouse CRF-R-2

Cat.:

U0241r

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96T

CLIA Kit for Mouse CRF-R-2

Cat.:

U0241m

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96T

Polyclonal Antibody for Mouse CRF-R-2

Cat.:

P0241Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse CRF-R-2

Cat.:

P0241Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse CRF-R-2

Cat.:

P0241Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse CRF-R-2

Protein for Mouse CRF-R-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.7%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤6.5%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of CRFR2 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	93-103
Plasma	98	95-100

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CRFR2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	95-100%	96-102%	95-99%	97-104%
EDTA plasma(n=5)	93-97%	95-100%	92-100%	96-102%
heparin plasma(n=5)	95-104%	93-104%	102-108%	91-97%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart."
Perrin M. , Donaldson C. , Chen R. , Blount A. , Berggren T. , Bilezikjian L. , Sawchenko P. , Vale W.
Proc. Natl. Acad. Sci. U.S.A.92:2969-2973(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF2-BETA)
tissue: Heart.
2.

"A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle."
Kishimoto T. , Pearse R.V. II , Lin C.R. , Rosenfeld M.G.
Proc. Natl. Acad. Sci. U.S.A.92:1108-1112(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF2-BETA)
strain: BALB/c.
tissue: Heart.
3.

"Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart."
Stenzel P. , Kesterson R. , Yeung W. , Cone R.D. , Rittenberg M.B. , Stenzel-Poore M.P.
Mol. Endocrinol.9:637-645(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF2-BETA)
strain: BALB/c.
tissue: Heart.
4.

"Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids."
Chen A. , Perrin M. , Brar B. , Li C. , Jamieson P. , DiGruccio M. , Lewis K. , Vale W.
Mol. Endocrinol.19:441-458(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF2-ALPHA)
strain: C57BL/6 X 129.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF2-BETA)
tissue: Brain.
6.

"NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor."
Grace C.R. , Perrin M.H. , DiGruccio M.R. , Miller C.L. , Rivier J.E. , Vale W.W. , Riek R.
Proc. Natl. Acad. Sci. U.S.A.101:12836-12841(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 39-133 (ISOFORM CRF2-BETA);DISULFIDE BONDS
7.

"The three-dimensional structure of the N-terminal domain of corticotropin-releasing factor receptors: sushi domains and the B1 family of G protein-coupled receptors."
Perrin M.H. , Grace C.R. , Riek R. , Vale W.W.
Ann. N. Y. Acad. Sci.1070:105-119(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 39-133 (ISOFORM CRF2-BETA) IN COMPLEX WITH PEPTIDE LIGAND;DISULFIDE BONDS;MUTAGENESIS OF ASP-45
8.

"Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand."
Grace C.R. , Perrin M.H. , Gulyas J. , Digruccio M.R. , Cantle J.P. , Rivier J.E. , Vale W.W. , Riek R.
Proc. Natl. Acad. Sci. U.S.A.104:4858-4863(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 39-133 (ISOFORM CRF2-BETA) IN COMPLEX WITH PEPTIDE LIGAND;DISULFIDE BONDS

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